Acute-phase-dependent binding affinity of C/EBPbeta from the nuclear extract and nuclear matrix towards the hormone response element of the alpha2-macroglobulin gene in rat hepatocytes.

نویسندگان

  • D Bogojević
  • M Mihailović
  • M Petrović
  • S Dinić
  • S Ivanović-Matić
  • G Poznanović
چکیده

Interactions of nuclear extract and nuclear matrix proteins from rat hepatocytes with the hormone response element of the alpha2-macroglobulin gene were studied. By Western and South-Western blot analysis we have shown the presence of C/EBPbeta in the examined nuclear fractions as well as its increased binding affinity to the examined gene sequence during the acute-phase response. The results suggest that both nuclear protein fractions could participate in the transcriptional regulation of the alpha2-macroglobulin gene in the rat hepatocytes.

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عنوان ژورنال:
  • General physiology and biophysics

دوره 22 2  شماره 

صفحات  -

تاریخ انتشار 2003